Ssbp3 Gene Summary [Mouse]
This gene encodes a member of the Ssdp (sequence-specific single-stranded DNA binding protein) family of proteins. The encoded protein binds specifically to single-stranded pyrimidine-rich DNA elements. The encoded protein has been shown to be important for head development and may play a role in the differentiation of spinal interneurons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Details
| Type | Processed Transcript |
| Official Symbol | Ssbp3 |
| Official Name | single-stranded DNA binding protein 3 [Source:MGI Symbol;Acc:MGI:1919725] |
| Ensembl ID | ENSMUSG00000061887 |
| Bio databases IDs | |
| Aliases | single-stranded DNA binding protein 3 |
| Synonyms | 2610021L12Rik, 2610200M23Rik, 5730488C10Rik, CSDP, LAST, LOC102549605, single-stranded DNA binding protein 3, SSDP, SSDP1, Ssdp3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ssbp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- single-stranded DNA binding
- protein binding
- Single-stranded DNA binding protein, SSDP
- LisH
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostate cancer
- prostatic carcinoma
- Fuchs endothelial dystrophy
- group 3 medulloblastoma
- brain cancer
- metabolic syndrome X
- hyperopia
- abdominal aortic aneurysm
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- histone H3
- protein-protein complex
- histone H2B
role in cell
- proliferation
- differentiation
- growth
- mono-ubiquitination in
- trimethylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ssbp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- positive regulation of cell proliferation
- prechordal plate formation
- positive regulation of anterior head development
- midbrain-hindbrain boundary initiation
- positive regulation of transcription from RNA polymerase II promoter
- mesendoderm development
- head morphogenesis
- hemopoietic progenitor cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- single-stranded DNA binding