Zar1 Gene Summary [Mouse]
Enables RNA sequestering activity; mRNA 3'-UTR binding activity; and molecular condensate scaffold activity. Involved in membraneless organelle assembly; oocyte maturation; and post-transcriptional regulation of gene expression. Is active in cytoplasm and intracellular membraneless organelle. Is expressed in early conceptus; ovary; and rib. Orthologous to human ZAR1 (zygote arrest 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Zar1 |
| Official Name | zygote arrest 1 [Source:MGI Symbol;Acc:MGI:2180337] |
| Ensembl ID | ENSMUSG00000063935 |
| Bio databases IDs | |
| Aliases | zygote arrest 1 |
| Synonyms | Z3CXXC6, zygote arrest 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zar1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- Zinc-binding domain
- protein binding activity, bridging
- protein binding
- translation regulator
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- organelle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zar1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oocyte maturation
- mRNA stabilization
- negative regulation of translation
- translation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular non-membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- mRNA 3'-UTR binding