Vrk1 Gene Summary [Mouse]
Enables protein serine/threonine kinase activity. Involved in regulation of neuron migration. Acts upstream of or within protein autophosphorylation. Located in nucleus. Is expressed in several structures, including dorsal mesogastrium; hemolymphoid system; liver; metanephros; and yolk sac. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 10 and pontocerebellar hypoplasia type 1A. Orthologous to human VRK1 (VRK serine/threonine kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vrk1 |
| Official Name | vaccinia related kinase 1 [Source:MGI Symbol;Acc:MGI:1261847] |
| Ensembl ID | ENSMUSG00000021115 |
| Bio databases IDs | |
| Aliases | vaccinia related kinase 1 |
| Synonyms | 51PK, AC163040.2, ENSMUSG00000113427, Gm40568, Gm46378, HMNR10, MRT32, PCH1, PCH1A, vaccinia related kinase 1, VRK serine/threonine kinase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vrk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- histone binding
- protein serine/threonine kinase
- protein kinase
- binding protein
- protein kinase binding
- Protein Kinases, catalytic domain
- chromatin binding
- protein binding
- enzyme
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioma formation
- insomnia
- rheumatoid arthritis
- pontocerebellar hypoplasia, type 1a
- prostate cancer
- epithelial cancer
- epithelial uterine cancer
- non-syndromic congenital pontocerebellar hypoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- cell death
- condensation
- proliferation
- expression in
- activation in
- processing in
- apoptosis
- disassembly
- migration
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- cytosol
- Golgi stacks
- chromosome
- nucleoplasm
- nucleoli
- Cajal bodies
- mitotic spindle
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vrk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- neuron projection development
- mitotic nuclear envelope disassembly
- Golgi disassembly
- protein autophosphorylation
- response to DNA damage stimulus
- protein phosphorylation
- cell division
- chromatin remodeling
- peptidyl-serine phosphorylation
- Cajal body organization
- regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- Cajal body
- cytosol
- nucleolus
- Golgi stack
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- protein binding
- histone binding
- histone kinase activity (H3-T3 specific)
- nucleosomal DNA binding
- histone kinase activity (H3-S10 specific)
- protein kinase activity
- protein serine/threonine kinase activity
- kinase activity