Izumo1r Gene Summary [Mouse]
Enables signaling receptor activity and signaling receptor binding activity. Involved in cell adhesion; fusion of sperm to egg plasma membrane involved in single fertilization; and sperm-egg recognition. Is active in plasma membrane. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; immune system; and liver and biliary system. Orthologous to human IZUMO1R (IZUMO1 receptor, JUNO). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Izumo1r |
| Official Name | IZUMO1 receptor, JUNO [Source:MGI Symbol;Acc:MGI:1929185] |
| Ensembl ID | ENSMUSG00000031933 |
| Bio databases IDs | |
| Aliases | IZUMO1 receptor, JUNO |
| Synonyms | 0910001L11Rik, Folbp3, FOLR4, FR-delta, FR-δ, IZUMO1 receptor, JUNO, JUNO, LOC686478 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Izumo1r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- protein binding
- receptor binding
- Folate receptor family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Izumo1r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm-egg recognition
- cell adhesion
- fusion of sperm to egg plasma membrane
- single fertilization
Cellular Component
Where in the cell the gene product is active
- microvillus membrane
- external side of plasma membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity
- receptor binding
- folic acid binding