Atp1a4 Gene Summary [Mouse]
Enables P-type sodium:potassium-exchanging transporter activity. Acts upstream of or within several processes, including flagellated sperm motility; sodium ion transport; and spermatogenesis. Predicted to be located in rod photoreceptor outer segment and sperm midpiece. Predicted to be part of sodium:potassium-exchanging ATPase complex. Predicted to be active in cell projection and plasma membrane. Is expressed in choroid plexus; epididymis; and testis. Orthologous to human ATP1A4 (ATPase Na+/K+ transporting subunit alpha 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp1a4 |
| Official Name | ATPase, Na+/K+ transporting, alpha 4 polypeptide [Source:MGI Symbol;Acc:MGI:1351335] |
| Ensembl ID | ENSMUSG00000007107 |
| Bio databases IDs | |
| Aliases | ATPase, Na+/K+ transporting, alpha 4 polypeptide |
| Synonyms | ATP1A1, ATP1AL2, ATPase, Na+/K+ transporting, alpha 4 polypeptide, ATPase Na+/K+ transporting subunit alpha 4, ATPase Na+/K+ transporting subunit α 4, ATPase, Na+/K+ transporting, α 4 polypeptide, LOC100365885, LOC102556675, Na, K-ATPasealpha4, Na, K-ATPaseα4, Na,K-ATPase α subunit 4, Sodium pump 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp1a4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cation transporter/ATPase, N-terminus
- sarco/endoplasmic reticulum calcium-translocating P-type ATPase
- cation-transporting ATPase
- heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
- golgi membrane calcium-translocating P-type ATPase
- Na+/K+-exchanging ATPase
- heavy metal translocating P-type ATPase
- protein binding
- plasma-membrane proton-efflux P-type ATPase
- E1-E2 ATPase
- P-type ATPase of unknown pump specificity (type V)
- copper-(or silver)-translocating P-type ATPase
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- plasma-membrane calcium-translocating P-type ATPase
- kinase binding
- Na,H/K antiporter P-type ATPase alpha subunit
- potassium and/or sodium efflux P-type ATPase, fungal-type
- Cation transport ATPase (P-type)
- Haloacid Dehalogenase-like Hydrolases
- transporter
- haloacid dehalogenase-like hydrolase
- Cation transporting ATPase, C-terminus
Pathways
Biological processes and signaling networks where the Atp1a4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- heart failure
- cardiovascular disorder
- schizophrenia
- asthenozoospermia
- Alzheimer disease
- persistent atrial fibrillation
- nephrosis
- nausea and vomiting
- agitation
regulates
- K+
- Na+
- FGF2
- H+
role in cell
- depolarization
- cell death
- fertilization
- morphology
- hyperactivation
- capacitation
- motility
- fertilization by
- function
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- non-motile cilium
- cellular membrane
- sperm midpiece
- neurites
- photoreceptor outer segments
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp1a4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
- spermatogenesis
- cellular sodium ion homeostasis
- fertilization
- cell surface receptor signaling pathway
- potassium ion transport
- sodium ion transport
- cellular potassium ion homeostasis
- ion transport
- regulation of membrane potential
- sperm motility
- establishment or maintenance of transmembrane electrochemical gradient
- sodium ion transmembrane transport
- establishment of localization in cell
- regulation of cellular pH
Cellular Component
Where in the cell the gene product is active
- sperm midpiece
- membrane raft
- sodium:potassium-exchanging ATPase complex
- cell projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- cation-transporting ATPase activity
- sodium:potassium-exchanging ATPase activity
- metal ion binding
- kinase binding