Krt2

Enables cytoskeletal protein binding activity. A structural constituent of skin epidermis. Involved in positive regulation of epidermis development. Acts upstream of or within intermediate filament organization and keratinocyte development. Located in cytoplasm and keratin filament. Is expressed in several structures, including gut; integumental system; male reproductive gland or organ; nervous system; and neural retina. Used to study bullous congenital ichthyosiform erythroderma. Human ortholog(s) of this gene implicated in bullous congenital ichthyosiform erythroderma and ichthyosis. Orthologous to human KRT2 (keratin 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Krt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Krt2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Krt2 gene, providing context for its role in the cell.