Krt15 Gene Summary [Mouse]
Predicted to enable scaffold protein binding activity. Predicted to be involved in epithelial cell differentiation and intermediate filament organization. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Is expressed in several structures, including alimentary system; genitourinary system; respiratory system; sensory organ; and skin. Orthologous to human KRT15 (keratin 15). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt15 |
| Official Name | keratin 15 [Source:MGI Symbol;Acc:MGI:96689] |
| Ensembl ID | ENSMUSG00000054146 |
| Bio databases IDs | |
| Aliases | keratin 15 |
| Synonyms | 50-kD Keratin, Basic cytokeratin, CK15, K15, K1CO, Ka15, keratin 15, KRT1-15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Krt15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of cytoskeleton
- protein binding
- Intermediate filament protein
Pathways
Biological processes and signaling networks where the Krt15 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- breast cancer
- atopic dermatitis
- eczema
- plaque psoriasis
- androgenic alopecia
- hypertrophic scarring
- chronic sinusitis
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
regulates
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- membrane surface
- intermediate filaments
- cytosol
- keratin intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Krt15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- epidermis development
- intermediate filament organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoskeleton
- cytosol
- intermediate filament
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- protein binding
- structural constituent of cytoskeleton