Krt2 Gene Summary [Rat]
Predicted to enable cytoskeletal protein binding activity. Predicted to be a structural constituent of skin epidermis. Predicted to be involved in several processes, including keratinocyte activation; keratinocyte migration; and keratinocyte proliferation. Predicted to act upstream of or within keratinocyte development. Predicted to be located in cornified envelope; cytosol; and intermediate filament cytoskeleton. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in bullous congenital ichthyosiform erythroderma and ichthyosis. Orthologous to human KRT2 (keratin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt2 |
| Official Name | keratin 2 [Source:RGD Symbol;Acc:1303297] |
| Ensembl ID | ENSRNOG00000009563 |
| Bio databases IDs | |
| Aliases | keratin 2 |
| Synonyms | CK-2e, K2e, Kb2, keratin 2, Keratin 2e, Krt2-17, Krt2-2, KRT2A, KRT2E, KRTE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Krt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Flagellar FliJ protein
- cytoskeletal protein binding
- structural constituent of cytoskeleton
- structural constituent of epidermis
- protein binding
- Intermediate filament protein
- Keratin type II head
Pathways
Biological processes and signaling networks where the Krt2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plaque psoriasis
- ichthyosis bullosa of Siemens
- psoriasis
- androgenic alopecia
- exfoliative ichthyosis
- epidermal hyperplasia
regulates
- DSP
- peptide
role in cell
- phosphorylation in
- proliferation
- migration
- activation
- development
- endocytosis by
- organization
- cytolysis
- destabilization in
- endocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cornified envelope
- intermediate filament cytoskeleton
- intermediate filaments
- cytosol
- keratin intermediate filaments
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Krt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinocyte proliferation
- positive regulation of epidermis development
- epidermis development
- keratinocyte activation
- keratinization
- peptide cross-linking
- intermediate filament organization
- keratinocyte development
- keratinocyte migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cornified envelope
- extracellular vesicular exosome
- keratin filament
- cytoplasm
- membrane
- cytosol
- intermediate filament
Molecular Function
What the gene product does at the molecular level
- structural constituent of epidermis
- protein binding
- structural constituent of cytoskeleton
- cytoskeletal protein binding