Ccdc146 Gene Summary [Mouse]
Acts upstream of or within several processes, including nucleus organization; single fertilization; and spermatid development. Predicted to be located in centriole and centrosome. Predicted to be active in cytoskeleton. Used to study male infertility. Human ortholog(s) of this gene implicated in spermatogenic failure 94. Orthologous to human CCDC146 (coiled-coil domain containing 146). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccdc146 |
| Official Name | coiled-coil domain containing 146 [Source:MGI Symbol;Acc:MGI:1922422] |
| Ensembl ID | ENSMUSG00000064280 |
| Bio databases IDs | |
| Aliases | coiled-coil domain containing 146 |
| Synonyms | 4930528G09Rik, coiled-coil domain containing 146, MBO2, mKIAA1505, SPGF94 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccdc146 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- binding protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- basal bodies
- centrosome
- centriole
- axonemes
- midbody
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccdc146 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid development
- sperm axoneme assembly
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoskeleton
- centriole
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding