Vps52 Gene Summary [Mouse]
Predicted to enable syntaxin binding activity. Involved in protein targeting and vesicle-mediated cholesterol transport. Acts upstream of or within ectodermal cell differentiation and embryonic ectodermal digestive tract development. Is active in postsynapse and presynapse. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. Orthologous to human VPS52 (VPS52 subunit of GARP complex). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps52 |
| Official Name | VPS52 GARP complex subunit [Source:MGI Symbol;Acc:MGI:1330304] |
| Ensembl ID | ENSMUSG00000024319 |
| Bio databases IDs | |
| Aliases | VPS52 GARP complex subunit |
| Synonyms | ARE1, D130068D18, D430041K17Rik, dJ1033B10.5, SAC2, SACM2L, tclw5, VPS52 GARP complex subunit, VPS52 subunit of GARP complex |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vps52 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Exocyst complex component Sec3
- protein binding
- Vps52 / Sac2 family
- syntaxin binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- presynaptic regions
- perinuclear region
- postsynaptic region
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- trans Golgi network
- endosomal membrane
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vps52 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting
- lysosomal transport
- protein transport
- ectodermal cell differentiation
- embryonic ectodermal digestive tract development
- retrograde transport, endosome to Golgi
- endocytic recycling
- vesicle-mediated cholesterol transport
- Golgi to vacuole transport
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- GARP complex
- membrane
- cytosol
- endosome membrane
- Golgi apparatus
- recycling endosome
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- syntaxin binding