Gmnn Gene Summary [Mouse]
Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in negative regulation of cell cycle; negative regulation of nucleobase-containing compound metabolic process; and protein-containing complex assembly. Acts upstream of or within animal organ morphogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and primitive streak. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 6. Orthologous to human GMNN (geminin DNA replication inhibitor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gmnn |
| Official Name | geminin [Source:MGI Symbol;Acc:MGI:1927344] |
| Ensembl ID | ENSMUSG00000006715 |
| Bio databases IDs | |
| Aliases | geminin |
| Synonyms | Gem, Geminin, geminin DNA replication inhibitor, geminin, DNA replication inhibitor, MGORS6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gmnn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- destruction box
- transcription co-repressor
- coiled-coil domain found in the geminin family
- transcription factor binding
- histone deacetylase binding
- coiled-coil domain
- chromatin binding
- protein binding
- Geminin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- epithelial cancer
- renal cell carcinoma
- renal cell cancer
- septic shock
- organismal death
- Meier-Gorlin syndrome type 6
- Meier-Gorlin syndrome
- Alzheimer disease
role in cell
- expression in
- proliferation
- apoptosis
- growth
- production in
- binding
- adhesion
- cell death
- phosphorylation in
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nucleosolic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gmnn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication preinitiation complex assembly
- positive regulation of chromatin binding
- negative regulation of transcription, DNA-dependent
- regulation of DNA-dependent DNA replication initiation
- negative regulation of cell cycle
- regulation of DNA replication
- negative regulation of DNA replication
- negative regulation of DNA-dependent DNA replication
- regulation of mitotic cell cycle
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- transcriptional repressor complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase binding
- transcription corepressor activity
- chromatin binding