Slc31a2 Gene Summary [Mouse]
Predicted to enable copper ion transmembrane transporter activity. Acts upstream of or within intracellular copper ion homeostasis and regulation of copper ion transmembrane transport. Located in late endosome; membrane; and recycling endosome. Is expressed in brain; retina nuclear layer; and urinary system. Orthologous to human SLC31A2 (solute carrier family 31 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc31a2 |
| Official Name | solute carrier family 31, member 2 [Source:MGI Symbol;Acc:MGI:1333844] |
| Ensembl ID | ENSMUSG00000066152 |
| Bio databases IDs | |
| Aliases | solute carrier family 31, member 2 |
| Synonyms | COPT2, CTR2, hCTR2, solute carrier family 31 member 2, solute carrier family 31, member 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc31a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- copper ion transporter
- Ctr copper transporter family
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic sclerosis
- lung cancer
- lung adenocarcinoma formation
- lung adenocarcinoma
- schizophrenia
regulates
- heavy metal
- cyclic AMP
- cisplatin
- Cu2+
- copper ion
role in cell
- accumulation in
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- lysosome membrane
- endosomal membrane
- recycling endosomes
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc31a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- copper ion transport
- cellular copper ion homeostasis
- copper ion transmembrane transport
- copper ion import
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- recycling endosome
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- copper ion transmembrane transporter activity