Slc26a2 Gene Summary [Mouse]
Enables solute:inorganic anion antiporter activity and sulfate transmembrane transporter activity. Involved in chondrocyte differentiation; chondrocyte proliferation; and sulfate transmembrane transport. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study diastrophic dysplasia. Human ortholog(s) of this gene implicated in bone disease (multiple). Orthologous to human SLC26A2 (solute carrier family 26 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc26a2 |
| Official Name | solute carrier family 26 (sulfate transporter), member 2 [Source:MGI Symbol;Acc:MGI:892977] |
| Ensembl ID | ENSMUSG00000034320 |
| Bio databases IDs | |
| Aliases | solute carrier family 26 (sulfate transporter), member 2 |
| Synonyms | D5S1708, diastrophic dysplasia sulphate transporter, DTD, DTDST, EDM4, MST153, MSTP157, solute carrier family 26 member 2, solute carrier family 26 (sulfate transporter), member 2, solute carrier family 26 (sulphate transporter), member 2, ST-OB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc26a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sulfate permease family
- PRK11660
- sulfate transporter
- high affinity sulphate transporter 1
- inorganic anion exchanger
- sulphate transporter and anti-sigma factor antagonist domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atelosteogenesis type II
- achondrogenesis type IB
- multiple epiphyseal dysplasia 4
- colon cancer
- diastrophic dysplasia
- osteochondrodysplasia
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- connective tissue disorder
- 3MC syndrome type 2
regulates
- sulfate
- hydroxide ion
- sialyl lewis X
- iodide
- oxalic acid
- sialyl 6-sulfo Lewis X
- chloride
- mitomycin C
- nitrate
- bromide
role in cell
- differentiation
- growth
- proliferation
- exchange in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc26a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sulfate transport
- ossification
- chondrocyte differentiation
- chondrocyte proliferation
- oxalate transport
- bicarbonate transport
Cellular Component
Where in the cell the gene product is active
- microvillus membrane
- extracellular vesicular exosome
- membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- secondary active sulfate transmembrane transporter activity
- oxalate transmembrane transporter activity
- inorganic anion exchanger activity
- chloride transmembrane transporter activity
- bicarbonate transmembrane transporter activity
- sulfate transmembrane transporter activity