Lsm14a Gene Summary [Mouse]
Enables double-stranded DNA binding activity; double-stranded RNA binding activity; and single-stranded RNA binding activity. Acts upstream of or within RIG-I signaling pathway; defense response to virus; and positive regulation of type I interferon-mediated signaling pathway. Located in P-body. Is expressed in several structures, including gonad. Orthologous to human LSM14A (LSM14A mRNA processing body assembly factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lsm14a |
| Official Name | LSM14A mRNA processing body assembly factor [Source:MGI Symbol;Acc:MGI:1914320] |
| Ensembl ID | ENSMUSG00000066568 |
| Bio databases IDs | |
| Aliases | LSM14A mRNA processing body assembly factor |
| Synonyms | 2700023B17RIK, AU017544, C19orf13, FAM61A, LSM14A mRNA processing body assembly factor, mRAP55A, RAP55, RAP55A, RGD1305695, Tral |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lsm14a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FDF domain
- Sm and related proteins
- Ataxin 2 SM domain
- double-stranded DNA binding
- double-stranded RNA binding
- protein binding
- single-stranded RNA binding
Pathways
Biological processes and signaling networks where the Lsm14a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- cytoplasmic mRNA processing body
- cytoplasmic aggregates
- cytosol
- stress granule
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lsm14a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stress granule assembly
- positive regulation of type I interferon-mediated signaling pathway
- cytoplasmic mRNA processing body assembly
- defense response to virus
- RIG-I signaling pathway
- negative regulation of translation
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- mitotic spindle
- cytoplasm
- cytosol
- cytoplasmic mRNA processing body
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- double-stranded RNA binding
- single-stranded RNA binding
- double-stranded DNA binding
- mRNA binding