Suds3 Gene Summary [Mouse]
Enables histone deacetylase binding activity and identical protein binding activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within blastocyst hatching. Part of Sin3-type complex. Is expressed in early conceptus; ovary; secondary oocyte; and seminiferous cord. Orthologous to human SUDS3 (SDS3 homolog, SIN3A corepressor complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Suds3 |
| Official Name | suppressor of defective silencing 3 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1919204] |
| Ensembl ID | ENSMUSG00000066900 |
| Bio databases IDs | |
| Aliases | suppressor of defective silencing 3 homolog (S. cerevisiae) |
| Synonyms | 2400003N08RIK, 2410008L21Rik, AU067672, LOC105378257, mSds3, RGD1305986, SAP45, SDS3, SDS3 homolog, SIN3A corepressor complex component, suppressor of defective silencing 3 homolog (S. cerevisiae) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Suds3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Sin3 binding domain
- enzyme binding
- histone deacetylase
- histone deacetylase binding
- coiled-coil domain
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Suds3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- major depression
- chromosomal instability
- hippocampal sclerosis of aging
role in cell
- proliferation
- apoptosis
- growth
- cell death
- cytokinesis
- aneuploidy
- remodeling
- segregation
- karyokinesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Suds3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- apoptotic process
- substantia nigra development
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytosol
- nucleoplasm
- Sin3-type complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase binding
- histone deacetylase activity
- enzyme binding