SUDS3 Gene Summary [Human]
SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | SUDS3 |
| Official Name | SDS3 homolog, SIN3A corepressor complex component [Source:HGNC Symbol;Acc:HGNC:29545] |
| Ensembl ID | ENSG00000111707 |
| Bio databases IDs | |
| Aliases | SDS3 homolog, SIN3A corepressor complex component, sin3A-associated protein, 45kDa |
| Synonyms | 2400003N08RIK, 2410008L21Rik, AU067672, LOC105378257, mSds3, RGD1305986, SAP45, SDS3, SDS3 homolog, SIN3A corepressor complex component, suppressor of defective silencing 3 homolog (S. cerevisiae) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SUDS3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Sin3 binding domain
- enzyme binding
- histone deacetylase
- histone deacetylase binding
- coiled-coil domain
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the SUDS3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- major depression
- chromosomal instability
- hippocampal sclerosis of aging
role in cell
- proliferation
- apoptosis
- growth
- cell death
- cytokinesis
- aneuploidy
- remodeling
- segregation
- karyokinesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SUDS3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- apoptotic process
- substantia nigra development
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytosol
- nucleoplasm
- Sin3-type complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase binding
- histone deacetylase activity
- enzyme binding