Eif1ax Gene Summary [Mouse]
Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Is active in synapse. Is expressed in cerebral cortex; cerebral cortex ventricular layer; and cortical plate. Orthologous to several human genes including EIF1AX (eukaryotic translation initiation factor 1A X-linked). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif1ax |
| Official Name | eukaryotic translation initiation factor 1A, X-linked [Source:MGI Symbol;Acc:MGI:1913485] |
| Ensembl ID | ENSMUSG00000067194 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 1A, X-linked |
| Synonyms | 1500010B24RIK, EIF1A, EIF1AP1, Eif1ay, EIF4C, eukaryotic translation initiation factor 1A X-linked, eukaryotic translation initiation factor 1A, X-linked, RGD1560198 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif1ax often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S1_like
- nucleic acid binding translation factor
- Translation initiation factor 1A / IF-1
- protein binding
- translation regulator
Pathways
Biological processes and signaling networks where the Eif1ax gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uveal melanoma
- ocular melanoma
- metastasis
- poorly differentiated thyroid carcinoma
- poorly differentiated thyroid cancer
- epithelial thyroid cancer
- follicular papillary thyroid carcinoma
- mixed papillary and follicular thyroid cancer
- Turner syndrome
- thyroid oncocytic carcinoma
role in cell
- cell death
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eif1ax gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosome assembly
- translational initiation
Cellular Component
Where in the cell the gene product is active
- multi-eIF complex
- cytoplasm
- eukaryotic 43S preinitiation complex
- cytosol
- eukaryotic 48S preinitiation complex
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- protein binding
- RNA binding
- translation factor activity, nucleic acid binding
- tRNA binding