Eif1 Gene Summary [Mouse]
Predicted to enable RNA binding activity; ribosomal small subunit binding activity; and translation initiation factor activity. Acts upstream of or within positive regulation of mRNA cis splicing, via spliceosome and random inactivation of X chromosome. Predicted to be located in cytoplasm and nucleus. Predicted to be part of eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; and multi-eIF complex. Is expressed in germ cell of testis and testis. Orthologous to human EIF1 (eukaryotic translation initiation factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif1 |
| Official Name | eukaryotic translation initiation factor 1 [Source:MGI Symbol;Acc:MGI:105125] |
| Ensembl ID | ENSMUSG00000035530 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 1 |
| Synonyms | A121, EIF1A, eukaryotic translation initiation factor 1, ISO1, SUI1, SUI1-RS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding translation factor
- Translation initiation factor SUI1
- translation initiation factor
- protein binding
- translation regulator
- Eukaryotic initiation factor 1 and related proteins
- ribosomal small subunit binding
Pathways
Biological processes and signaling networks where the Eif1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- tumorigenesis
- COVID-19
- endometriosis
- systemic juvenile idiopathic arthritis
- atopic dermatitis
role in cell
- growth
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eif1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- translational initiation
- regulation of translational initiation
Cellular Component
Where in the cell the gene product is active
- multi-eIF complex
- nucleus
- cytoplasm
- eukaryotic 43S preinitiation complex
- eukaryotic 48S preinitiation complex
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- protein binding
- RNA binding
- ribosomal small subunit binding
- translation factor activity, nucleic acid binding