Spin1 Gene Summary [Mouse]
Enables histone reader activity and methylated histone binding activity. Involved in protein localization to chromatin and transposable element silencing by piRNA-mediated DNA methylation. Located in spindle. Is active in chromatin. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human SPIN1 (spindlin 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spin1 |
| Official Name | spindlin 1 [Source:MGI Symbol;Acc:MGI:109242] |
| Ensembl ID | ENSMUSG00000021395 |
| Bio databases IDs | |
| Aliases | spindlin 1 |
| Synonyms | AA553322, NEWGENE 1306210, SPIN, spindlin 1, SSEC P, TDRD24 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spin1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- Spin/Ssty Family
- protein binding activity, bridging
- protein binding
Pathways
Biological processes and signaling networks where the Spin1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- advanced cancer
- cancer
- neoplasia
- cervical cancer
role in cell
- migration
- apoptosis
- expression in
- binding in
- proliferation
- cell death
- invasion by
- tubulation by
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- cytosol
- nucleoplasm
- nucleoli
- nuclear envelope
- meiotic spindles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spin1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic cell cycle
- positive regulation of transcription, DNA-dependent
- rRNA transcription
- Wnt receptor signaling pathway
- regulation of transcription, DNA-dependent
- gamete generation
- positive regulation of Wnt receptor signaling pathway
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- spindle
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- methylated histone residue binding