Ipo8 Gene Summary [Mouse]
Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in protein import into nucleus. Predicted to be located in plasma membrane. Predicted to be active in cytosol and nuclear envelope. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system. Orthologous to human IPO8 (importin 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ipo8 |
| Official Name | importin 8 [Source:MGI Symbol;Acc:MGI:2444611] |
| Ensembl ID | ENSMUSG00000040029 |
| Bio databases IDs | |
| Aliases | importin 8 |
| Synonyms | 6230418K12Rik, AABR07062570.1, Abcc10, C130009K11Rik, IMP8, importin 8, MRP7, OM-1, RANBP8, VISS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ipo8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase activity, coupled to transmembrane movement of substances
- enzyme binding
- protein binding
- Importin-beta N-terminal domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ipo8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- protein import into nucleus
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding