Exoc4 Gene Summary [Mouse]
Enables PDZ domain binding activity. Acts upstream of or within paraxial mesoderm formation and protein transmembrane transport. Located in growth cone membrane; microvillus; and myelin sheath abaxonal region. Is expressed in several structures, including central nervous system; extraembryonic component; ganglia; and retina. Orthologous to human EXOC4 (exocyst complex component 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Exoc4 |
| Official Name | exocyst complex component 4 [Source:MGI Symbol;Acc:MGI:1096376] |
| Ensembl ID | ENSMUSG00000029763 |
| Bio databases IDs | |
| Aliases | exocyst complex component 4 |
| Synonyms | ALR, exocyst complex component 4, LOC105375513, RSEC8, SEC8, SEC8L1, Sec8p |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Exoc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding
- ionotropic glutamate receptor binding
- transporter
- PDZ-domain binding
Pathways
Biological processes and signaling networks where the Exoc4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- cervical cancer
- Waldenström macroglobulinemia
- breast adenocarcinoma
- non-small cell lung cancer
- schizophrenia
- cervical carcinoma
- nephrosis
- epithelial uterine cancer
- Alzheimer disease
regulates
- D-glucose
- Ca2+
- tubulin
role in cell
- differentiation
- formation
- formation in
- biogenesis
- formation by
- outgrowth
- outgrowth in
- targeting
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- soluble fraction
- low-density microsomal fraction
- organelle
- perinuclear region
- Plasma Membrane
- endosomes
- centrosome
- lysosome
- midbody
- cytosol
- myelin sheath outer loop
- synaptic vesicles
- growth cone
- neurites
- myelin sheath inner loop
- synapse
- Schmidt-Lanterman incisures
- perinuclear vesicles
- actin stress fibers
- tight junctions
- microvilli
- cell membrane leading edge
- perikaryon
- axons
- dendrites
- postsynaptic density
- dendritic shafts
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Exoc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transmembrane transport
- paraxial mesoderm formation
- membrane fission
- cytokinesis after mitosis
- vesicle docking involved in exocytosis
- Golgi to plasma membrane transport
- regulation of macroautophagy
- synaptic transmission
- exocytosis
Cellular Component
Where in the cell the gene product is active
- centrosome
- microvillus
- cytoplasm
- membrane
- cytosol
- growth cone membrane
- synapse
- myelin sheath abaxonal region
- plasma membrane
- exocyst
Molecular Function
What the gene product does at the molecular level
- protein binding
- PDZ domain binding