Rac2 Gene Summary [Mouse]
Enables GTPase activity and protein kinase regulator activity. Involved in several processes, including positive regulation of lamellipodium assembly; regulation of leukocyte chemotaxis; and regulation of mast cell degranulation. Acts upstream of or within several processes, including cell projection assembly; erythrocyte enucleation; and positive regulation of mast cell proliferation. Located in cytoplasm; membrane; and nuclear envelope. Is expressed in heart; maxilla; palatal shelf; and secondary palate. Used to study immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia. Human ortholog(s) of this gene implicated in immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis; immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia; and immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia. Orthologous to human RAC2 (Rac family small GTPase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rac2 |
| Official Name | Rac family small GTPase 2 [Source:MGI Symbol;Acc:MGI:97846] |
| Ensembl ID | ENSMUSG00000033220 |
| Bio databases IDs | |
| Aliases | Rac family small GTPase 2 |
| Synonyms | AI452260, EN-7, Gx, HSPC022, IMD73A, IMD73B, IMD73C, p21-Rac2, Rac family small GTPase 2, Ras-related c3 botulinum substrate 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rac2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- effector loop
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- protein kinase regulator
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- beta strand or sheet
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- basic domain
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rac2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Agrin Interactions at Neuromuscular Junction
- Apelin Adipocyte Signaling Pathway
- CXCR4 Signaling
- Endocannabinoid Developing Neuron Pathway
- Ephrin B Signaling
- Ephrin Receptor Signaling
- Fc Epsilon RI Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- fMLP Signaling in Neutrophils
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- HIF1α Signaling
- Molecular Mechanisms of Cancer
- Netrin Signaling
- Phagosome Maturation
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- PTEN Signaling
- Regulation of Actin-based Motility by Rho
- Semaphorin Signaling in Neurons
- Thrombin Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- cancer
- adenoma formation
- nonalcoholic steatohepatitis
- diffuse systemic sclerosis
- poikilocytosis
- B cell and T cell lymphocytopenia
- non-insulin-dependent diabetes mellitus
- androgenic alopecia
- immunodeficiency 73C with defective neutrophil chemotaxis and hypogammaglobulinemia
role in cell
- growth
- apoptosis
- expression in
- activation in
- migration
- inhibition in
- proliferation
- phosphorylation in
- cell viability
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- high-density microsomal fractions
- raft fractions
- membrane fraction
- cellular membrane
- Nucleus
- Plasma Membrane
- actin filaments
- cytosol
- endoplasmic reticulum membrane
- mitochondrial outer membrane
- perinuclear space
- nuclear envelope
- membrane rafts
- phagosomes
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rac2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of T cell proliferation
- positive regulation of lamellipodium assembly
- G-protein coupled receptor signaling pathway
- signal transduction
- small GTPase mediated signal transduction
- cell projection assembly
- positive regulation of neutrophil chemotaxis
- regulation of respiratory burst
- actin filament organization
- respiratory burst
- regulation of mast cell chemotaxis
- regulation of mast cell degranulation
- lymphocyte aggregation
- chemotaxis
- mast cell proliferation
- bone resorption
- enucleation
- regulation of cell-substrate adhesion
- regulation of hydrogen peroxide metabolic process
- positive regulation of mast cell proliferation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- NADPH oxidase complex
- focal adhesion
- phagocytic vesicle membrane
- cytosol
- mitochondrial outer membrane
- actin filament
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- protein kinase regulator activity