Rdh16 Gene Summary [Mouse]
Enables all-trans-retinol dehydrogenase (NAD+) activity and identical protein binding activity. Involved in retinoid metabolic process and steroid metabolic process. Acts upstream of or within 9-cis-retinoic acid biosynthetic process. Located in endoplasmic reticulum lumen and endoplasmic reticulum membrane. Is expressed in alimentary system; embryo; future spinal cord; liver; and salivary gland. Orthologous to human RDH16 (retinol dehydrogenase 16). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Rdh16 |
| Official Name | retinol dehydrogenase 16 [Source:MGI Symbol;Acc:MGI:1201375] |
| Ensembl ID | ENSMUSG00000069456 |
| Bio databases IDs | |
| Aliases | retinol dehydrogenase 16 |
| Synonyms | CRAD, CRAD1, hRDH-E, Rdh6, retinol dehydrogenase 16, RODH-4, SDR9C8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rdh16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- electron carrier
- sepiapterin reductase
- 3alpha(or 20beta)-hydroxysteroid dehydrogenase
- retinol dehydrogenase
- 3(or 17)alpha-hydroxysteroid dehydrogenase
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
- identical protein binding
Pathways
Biological processes and signaling networks where the Rdh16 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- breast cancer
- liver cancer
- nonalcoholic fatty liver disease
- hepatocellular carcinoma
- epithelial cancer
- hepatitis B virus-related hepatocellular carcinoma
- progressive familial intrahepatic cholestasis type 1
role in cell
- integrity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- microsome
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rdh16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid metabolic process
- retinol metabolic process
- steroid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- androstan-3-alpha,17-beta-diol dehydrogenase activity
- identical protein binding
- retinol dehydrogenase activity
- electron carrier activity
- androsterone dehydrogenase activity