Rbp1 Gene Summary [Mouse]
Enables all-trans-retinol binding activity. Involved in lipid storage and retinoid metabolic process. Acts upstream of or within regulation of granulocyte differentiation; response to vitamin A; and retinoid metabolic process. Located in lipid droplet. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; embryo mesenchyme; and genitourinary system. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to human RBP1 (retinol binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbp1 |
| Official Name | retinol binding protein 1, cellular [Source:MGI Symbol;Acc:MGI:97876] |
| Ensembl ID | ENSMUSG00000046402 |
| Bio databases IDs | |
| Aliases | retinol binding protein 1, cellular |
| Synonyms | CRABP-I, CRBP, CRBP1, CRBPI, hCRBP1, LOC100045055, RBPC, retinol binding protein 1, retinol binding protein 1, cellular |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helical cap
- lipocalin/cytosolic fatty acid-binding protein family
- retinol binding
- protein binding
- retinoid binding
- Lipocalin / cytosolic fatty-acid binding protein family
- transporter
Pathways
Biological processes and signaling networks where the Rbp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- hyperplasia
- organismal death
- uterine leiomyoma
- leiomyomatosis
- hyperglycemia
- aortic valve calcification
- growth failure
role in cell
- number
- expression in
- survival
- differentiation
- proliferation
- migration
- binding
- accumulation in
- cellular infiltration by
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- nuclear fraction
- Cytoplasm
- Nucleus
- lipid droplets
- cytosol
- nucleoplasm
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retinoic acid biosynthetic process
- fatty acid transport
- lipid homeostasis
- vitamin A metabolic process
Cellular Component
Where in the cell the gene product is active
- lipid particle
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- fatty acid binding
- protein binding
- retinal binding
- retinoid binding