Tmem100 Gene Summary [Mouse]
Involved in positive regulation of endothelial cell differentiation; positive regulation of vasculogenesis; and regulation of sensory perception of pain. Acts upstream of or within several processes, including Notch signaling pathway; circulatory system development; and regulation of intracellular signal transduction. Located in perikaryon; perinuclear region of cytoplasm; and plasma membrane. Is expressed in several structures, including cardiovascular system; eye; genitourinary system; hemolymphoid system gland; and spinal cord. Orthologous to human TMEM100 (transmembrane protein 100). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem100 |
| Official Name | transmembrane protein 100 [Source:MGI Symbol;Acc:MGI:1915138] |
| Ensembl ID | ENSMUSG00000069763 |
| Bio databases IDs | |
| Aliases | transmembrane protein 100 |
| Synonyms | 1810057C19Rik, FLJ10970, transmembrane protein 100 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem100 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transmembrane protein 100
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- non-small cell lung cancer
- non-small cell lung carcinoma
- idiopathic pulmonary fibrosis
- lung cancer
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear region
- Endoplasmic Reticulum
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem100 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial to mesenchymal transition involved in endocardial cushion formation
- vasculogenesis
- positive regulation of endothelial cell differentiation
- arterial endothelial cell differentiation
- Notch signaling pathway
- in utero embryonic development
- cellular response to BMP stimulus
- angiogenesis
- BMP signaling pathway
- positive regulation of vasculogenesis
- regulation of calcium-mediated signaling
- regulation of sensory perception of pain
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- endoplasmic reticulum
- perikaryon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding