F11r Gene Summary [Mouse]
Predicted to enable PDZ domain binding activity; integrin binding activity; and protein homodimerization activity. Involved in intestinal absorption; regulation of cytokine production; and regulation of membrane permeability. Acts upstream of or within cell adhesion and epithelial cell differentiation. Located in bicellular tight junction. Is expressed in several structures, including 4-8 cell stage embryo; alimentary system; forebrain; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human F11R (F11 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | F11r |
| Official Name | F11 receptor [Source:MGI Symbol;Acc:MGI:1321398] |
| Ensembl ID | ENSMUSG00000038235 |
| Bio databases IDs | |
| Aliases | F11 receptor |
| Synonyms | 9130004G24, CD321, ESTM33, F11 receptor, JAM, JAM-1, JAM-A, JCAM, Jcam1, KAT, Ly106, PAM-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse F11r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Immunoglobulin C1-set domain
- Immunoglobulin V-Type
- ectodomain
- immunoglobulin domain
- Immunoglobulin I-set domain
- signal peptide
- protein binding
- zDHHC ankyrin repeat binding domain
- PDZ-domain binding
- cytoplasmic domain
- Immunoglobulin like
- integrin binding
- transmembrane domain
- protein homodimerization
- immunoglobulin-like protein domain
- cytosolic tail domain
- PDZ binding motif
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the F11r gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- breast cancer
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- androgenic alopecia
- arterial aneurysm and dissection
- delayed hypersensitive reaction
- Waldenström macroglobulinemia
- polyarticular juvenile rheumatoid arthritis
role in cell
- phosphorylation in
- proliferation
- activation in
- morphology
- migration
- binding
- differentiation
- formation
- function
- permeability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- button-like junction
- cell junction
- cell surface
- basal compartment
- cellular membrane
- Nucleus
- intercellular junctions
- cell-cell contacts
- tight junctions
- lateral cell-cell contacts
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse F11r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- viral entry into host cell
- memory T cell extravasation
- positive regulation of Rho protein signal transduction
- actomyosin structure organization
- leukocyte cell-cell adhesion
- cellular response to mechanical stimulus
- inflammatory response
- negative regulation of stress fiber assembly
- intestinal absorption
- regulation of actin cytoskeleton organization
- regulation of cytoskeleton organization
- regulation of cytokine production
- regulation of tight junction assembly
- protein localization in plasma membrane
- maintenance of blood-brain barrier
Cellular Component
Where in the cell the gene product is active
- tight junction
- occluding junction
- cell-cell junction
- extracellular vesicular exosome
- cell junction
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- cadherin binding
- PDZ domain binding
- viral receptor activity
- integrin binding