Setdb2 Gene Summary [Mouse]
Predicted to enable histone H3K9 methyltransferase activity. Predicted to be involved in several processes, including heterochromatin organization; left/right pattern formation; and negative regulation of macromolecule biosynthetic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including gonad; nervous system; and nose. Orthologous to human SETDB2 (SET domain bifurcated histone lysine methyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Setdb2 |
| Official Name | SET domain, bifurcated 2 [Source:MGI Symbol;Acc:MGI:2685139] |
| Ensembl ID | ENSMUSG00000071350 |
| Bio databases IDs | |
| Aliases | SET domain, bifurcated 2 |
| Synonyms | C13orf4, CLLD8, CLLL8, Gm293, H3-K9-HMTase, KMT1F, LOC102552532, SET domain, bifurcated 2, SET domain bifurcated histone lysine methyltransferase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Setdb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone lysine N-methyltransferase activity (H3-K9 specific)
- Pre-SET motif
- histone methyltransferase
- PHD-like zinc-binding domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- SET domain
- PHD finger superfamily
- enzyme
- protein binding
- MBD
- N-terminal to some SET domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Setdb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- negative regulation of gene expression
- heterochromatin organization
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- chromosome segregation
- heart looping
- positive regulation of methylation-dependent chromatin silencing
- mitotic cell cycle
- left/right axis specification
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- histone methyltransferase activity (H3-K9 specific)