Sp110 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within positive regulation of apoptotic process and response to bacterium. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; genitourinary system; and thymus primordium. Human ortholog(s) of this gene implicated in hepatic venoocclusive disease with immunodeficiency and tuberculosis. Orthologous to human SP110 (SP110 nuclear body protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Sp110 |
| Official Name | Sp110 nuclear body protein [Source:MGI Symbol;Acc:MGI:1923364] |
| Ensembl ID | ENSMUSG00000070034 |
| Bio databases IDs | |
| Aliases | Sp110 nuclear body protein |
| Synonyms | 5031415C07Rik, 5830484A20Rik, AC168977.1, Gm15753, Gm16026, Ifi75, Ipr1, LOC102634459, LOC102638047, LOC108168675, LOC677525, MGC118608, Sp110 nuclear body protein, sp110 nuclear body protein-like, Sp110 nuclear body protein, pseudogene 1, Sp110 nuclear body protein, pseudogene 2, Sp110-ps1, Sp110-ps2 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sp110 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SAND domain
- HSR domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
role in cell
- expression in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm