Tbpl1 Gene Summary [Mouse]
Predicted to enable RNA polymerase II core promoter sequence-specific DNA binding activity and RNA polymerase II general transcription initiation factor activity. Acts upstream of or within acrosome assembly; dTTP biosynthetic process; and spermatid nucleus differentiation. Located in cytoplasm and male germ cell nucleus. Part of transcription factor TFIIA complex. Is expressed in several structures, including central nervous system; early conceptus; ganglia; gonad; and sensory organ. Orthologous to human TBPL1 (TATA-box binding protein like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbpl1 |
| Official Name | TATA box binding protein-like 1 [Source:MGI Symbol;Acc:MGI:1339946] |
| Ensembl ID | ENSMUSG00000071359 |
| Bio databases IDs | |
| Aliases | TATA box binding protein-like 1 |
| Synonyms | 4732475G08, MGC:8389, MGC:9620, STD, STUD, TATA box binding protein-like 1, TLF, TLP, TRF2, TRP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tbpl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- general RNA polymerase II transcription factor
- sequence-specific DNA binding
- tandem repeat
- TBP_TLF
- TRAF-C subdomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostate cancer
- oligozoospermia
- azoospermia
- prostatic carcinoma
role in cell
- expression in
- apoptosis
- activation in
- proliferation
- number
- fragmentation
- transcription in
- differentiation
- recruitment in
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleolar fraction
- Cytoplasm
- perinuclear region
- nucleoplasm
- nucleoli
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tbpl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acrosome assembly
- spermatid nucleus differentiation
- transcription from RNA polymerase II promoter
- transcription initiation, DNA-dependent
- dTTP biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- transcription factor TFIIA complex
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter sequence-specific DNA binding
- general RNA polymerase II transcription factor activity