Gtf2a1 Gene Summary [Mouse]
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in positive regulation of transcription initiation by RNA polymerase II and transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription factor TFIIA complex. Is expressed in several structures, including early conceptus; genitourinary system; liver; olfactory epithelium; and spleen. Orthologous to human GTF2A1 (general transcription factor IIA subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gtf2a1 |
| Official Name | general transcription factor II A, 1 [Source:MGI Symbol;Acc:MGI:1933277] |
| Ensembl ID | ENSMUSG00000020962 |
| Bio databases IDs | |
| Aliases | general transcription factor II A, 1 |
| Synonyms | 6330549H03RIK, general transcription factor 2A subunit 1, general transcription factor II A, 1, general transcription factor IIA subunit 1, Tf2a, TF2A1, TFIIA, Tfiia1, TFIIA-42, TfIIAa/b, TFIIA alpha/beta, TFIIAL, TFIIA α/β, TFIIA β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gtf2a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transcription factor IIA, alpha/beta subunit
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- transcription factor binding
- protein binding
- general RNA polymerase II transcription factor
- sequence-specific DNA binding
- TATA-binding protein binding
- protein heterodimerization
- DNA binding
Pathways
Biological processes and signaling networks where the Gtf2a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gtf2a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- cytosol
- transcription factor TFIIA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- protein heterodimerization activity
- RNA polymerase II core promoter sequence-specific DNA binding
- general RNA polymerase II transcription factor activity
- RNA polymerase II basal transcription factor binding
- TBP-class protein binding