Piwil1 Gene Summary [Mouse]
Enables several functions, including RNA binding activity; mRNA cap binding complex binding activity; and protein kinase binding activity. Involved in regulatory ncRNA-mediated gene silencing and sperm DNA condensation. Located in chromatoid body; dense body; and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; and lung. Orthologous to human PIWIL1 (piwi like RNA-mediated gene silencing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Piwil1 |
| Official Name | piwi-like RNA-mediated gene silencing 1 [Source:MGI Symbol;Acc:MGI:1928897] |
| Ensembl ID | ENSMUSG00000029423 |
| Bio databases IDs | |
| Aliases | piwi-like RNA-mediated gene silencing 1 |
| Synonyms | CT80.1, HIWI, LOC102724010, MIWI, PIWI, PIWI1, piwi-like RNA-mediated gene silencing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Piwil1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Piwi-like
- protein kinase binding
- mRNA binding
- PAZ domain
- enzyme
- protein binding
- single-stranded RNA binding
- Piwi domain
- RNA binding
- binding protein
- GAGE protein
- Argonaute linker 1 domain
- endoribonuclease
- PAZ
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- epithelial ovarian cancer
- ovarian cancer
- metastasis
- gastric adenocarcinoma
- gastric epithelial cancer
- male infertility
role in cell
- proliferation
- expression in
- apoptosis
- migration
- binding in
- cell cycle progression
- development
- ubiquitination in
- translation in
- condensation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- punctate structures
- Nucleus
- polysomes
- cytosol
- sister chromatids
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Piwil1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- meiotic cell cycle
- spermatid development
- spermatogenesis
- sperm chromatin condensation
- gene silencing by RNA
- piRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatoid body
- cytoplasm
- P granule
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- piRNA binding
- metal ion binding
- single-stranded RNA binding
- mRNA binding
- endoribonuclease activity