Efcab7 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Involved in several processes, including positive regulation of protein localization; positive regulation of transcription by RNA polymerase II; and protein localization to motile cilium. Located in ciliary membrane and cytoplasmic side of plasma membrane. Part of plasma membrane protein complex. Is expressed in skin. Orthologous to human EFCAB7 (EF-hand calcium binding domain 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Efcab7 |
| Official Name | EF-hand calcium binding domain 7 [Source:MGI Symbol;Acc:MGI:2385199] |
| Ensembl ID | ENSMUSG00000073791 |
| Bio databases IDs | |
| Aliases | EF-hand calcium binding domain 7 |
| Synonyms | EF-hand calcium binding domain 7, mKIAA1799, RGD1561825 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Efcab7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand domain pair
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- EFh
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cilia
- cytoplasmic face of plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Efcab7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein import into nucleus
- positive regulation of transcription from RNA polymerase II promoter
- regulation of smoothened signaling pathway
Cellular Component
Where in the cell the gene product is active
- cilium
- cilium membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding