Akap14 Gene Summary [Mouse]

This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The human ortholog of this gene has been characterized. It is reported to be enriched in airway cilia and to regulate ciliary beat frequency by anchoring the protein kinase A holoenzyme near substrates in the axoneme. [provided by RefSeq, May 2013]

Details

Type
Protein Coding
Official Symbol
Akap14
Official Name
A kinase (PRKA) anchor protein 14 [Source:MGI Symbol;Acc:MGI:3618288]
Ensembl ID
ENSMUSG00000036551
Bio databases IDs NCBI: 434756 Ensembl: ENSMUSG00000036551
Aliases A kinase (PRKA) anchor protein 14
Synonyms AKAP28, A-kinase anchoring protein 14, A kinase anchor protein 14, PRKA14
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akap14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein kinase A binding
  • protein binding
  • 28 kDa A-kinase anchor

Pathways

Biological processes and signaling networks where the Akap14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • COVID-19

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • cilia
  • axonemes
  • sperm fibrous sheath

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Akap14 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • axoneme
  • cAMP-dependent protein kinase complex

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • protein kinase A regulatory subunit binding

Gene-Specific Assays for Results You Can Trust

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