Trim68 Gene Summary [Mouse]
Predicted to enable several functions, including histone acetyltransferase binding activity; identical protein binding activity; and nuclear androgen receptor binding activity. Predicted to be involved in several processes, including innate immune response; protein autoubiquitination; and regulation of androgen receptor signaling pathway. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be active in cytosol and nucleoplasm. Is expressed in central nervous system and genitourinary system. Orthologous to human TRIM68 (tripartite motif containing 68). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim68 |
| Official Name | tripartite motif-containing 68 [Source:MGI Symbol;Acc:MGI:2142077] |
| Ensembl ID | ENSMUSG00000073968 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 68 |
| Synonyms | F730114J12Rik, GC109, RNF137, SS-56, tripartite motif-containing 68 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim68 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPRY domain
- zinc finger of C3HC4-type, RING
- androgen receptor binding
- enzyme
- Ring finger domain
- protein binding
- identical protein binding
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- B-box zinc finger
- SPRY-associated domain
- histone acetyltransferase binding
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Golgi Apparatus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim68 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- regulation of viral entry into host cell
- regulation of protein localization
- innate immune response
- protein polyubiquitination
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of NF-kappaB transcription factor activity
- regulation of androgen receptor signaling pathway
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- Golgi apparatus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein kinase binding
- zinc ion binding
- histone acetyltransferase binding
- identical protein binding
- protein binding
- protein homodimerization activity
- androgen receptor binding