Ifi30 Gene Summary [Mouse]
Predicted to enable oxidoreductase activity, acting on a sulfur group of donors. Involved in antigen processing and presentation of exogenous peptide antigen via MHC class I. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of fibroblast proliferation; and protein stabilization. Located in lysosome. Is expressed in gut; liver; orbito-sphenoid; and submandibular gland primordium. Orthologous to human IFI30 (IFI30 lysosomal thiol reductase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ifi30 |
| Official Name | interferon gamma inducible protein 30 [Source:MGI Symbol;Acc:MGI:2137648] |
| Ensembl ID | ENSMUSG00000031838 |
| Bio databases IDs | |
| Aliases | interferon gamma inducible protein 30 |
| Synonyms | gamma-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE, GILT, IFI30 lysosomal thiol reductase, IFI30, lysosomal thiol reductase, IFN-30, interferon gamma inducible protein 30, interferon γ inducible protein 30, IP-30, γ-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ifi30 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfur group oxidoreductase
- disulfide oxidoreductase
- signal peptide
- enzyme
- protein binding
- Gamma interferon inducible lysosomal thiol reductase (GILT)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- peripheral arterial disease
- atopic dermatitis
- skin basal cell carcinoma
- basal cell skin cancer
- psoriasis
- cutaneous T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- skin cancer
role in cell
- expression in
- activation in
- proliferation
- growth
- viral entry in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- intracellular membrane-bounded organelle
- cell surface
- Extracellular Space
- lysosome
- cytosol
- MHC class II compartments
- lysosomal compartment
- early endosomes
- late endosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ifi30 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- antigen processing and presentation of exogenous peptide antigen via MHC class I
- negative regulation of fibroblast proliferation
- protein stabilization
- antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cell junction
- cytosol
- lysosomal lumen
- extracellular region
- lysosome
Molecular Function
What the gene product does at the molecular level
- oxidoreductase activity, acting on a sulfur group of donors
- protein binding
- oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor