Fign Gene Summary [Mouse]
Predicted to enable ATP hydrolysis activity and microtubule severing ATPase activity. Acts upstream of or within locomotory behavior. Located in nuclear matrix. Is expressed in central nervous system and heart. Orthologous to human FIGN (fidgetin, microtubule severing factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fign |
| Official Name | fidgetin [Source:MGI Symbol;Acc:MGI:1890647] |
| Ensembl ID | ENSMUSG00000075324 |
| Bio databases IDs | |
| Aliases | fidgetin |
| Synonyms | Fgn, fi, fidget, fidgetin, fidgetin, microtubule severing factor, LOC100503277 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fign often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fign gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- microtubule cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- nuclear matrix
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- microtubule-severing ATPase activity