Orc3 Gene Summary [Mouse]
Predicted to enable DNA replication origin binding activity. Acts upstream of or within glial cell proliferation and neural precursor cell proliferation. Predicted to be located in chromatin and nuclear body. Predicted to be part of DNA replication preinitiation complex; nuclear origin of replication recognition complex; and nuclear pre-replicative complex. Orthologous to human ORC3 (origin recognition complex subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Orc3 |
| Official Name | origin recognition complex, subunit 3 [Source:MGI Symbol;Acc:MGI:1354944] |
| Ensembl ID | ENSMUSG00000040044 |
| Bio databases IDs | |
| Aliases | origin recognition complex, subunit 3 |
| Synonyms | LAT, LATHEO, ORC3L, origin recognition complex subunit 3, origin recognition complex, subunit 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Orc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MOD1-interacting region
- Origin recognition complex winged helix C-terminal
- Origin recognition complex subunit 3
- Origin recognition complex subunit 3 insertion domain
- DNA replication origin binding
- coiled-coil domain
- protein binding
Pathways
Biological processes and signaling networks where the Orc3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- soluble fraction
- chromatin fraction
- nuclear matrix fraction
- heterochromatic focus
- nuclear foci
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Orc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
- DNA replication
- neural precursor cell proliferation
- regulation of DNA replication
- glial cell proliferation
Cellular Component
Where in the cell the gene product is active
- pre-replicative complex
- origin recognition complex
- nucleus
- chromosome, telomeric region
- nuclear body
- DNA replication preinitiation complex
- nuclear origin of replication recognition complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA replication origin binding
- protein binding