Slc2a12 Gene Summary [Mouse]
Predicted to enable D-glucose transmembrane transporter activity. Acts upstream of or within D-glucose transmembrane transport. Located in membrane. Is expressed in several structures, including adipose tissue; eye; female reproductive system; heart; and nervous system. Orthologous to human SLC2A12 (solute carrier family 2 member 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc2a12 |
| Official Name | solute carrier family 2 (facilitated glucose transporter), member 12 [Source:MGI Symbol;Acc:MGI:3052471] |
| Ensembl ID | ENSMUSG00000037490 |
| Bio databases IDs | |
| Aliases | solute carrier family 2 (facilitated glucose transporter), member 12 |
| Synonyms | GLUT-12, GLUT8, solute carrier family 2 (facilitated glucose transporter), member 12, solute carrier family 2 member 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc2a12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hexose transporter
- benzoate transport
- Sugar (and other) transporter
- MFS transporter, sugar porter (SP) family
- Major Facilitator Superfamily
- Multidrug resistance protein
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- renal clear cell adenocarcinoma
- open-angle glaucoma
- renal clear cell cancer
- prostatic carcinoma
- prostate cancer
- coronary artery disease
- dilated cardiomyopathy
regulates
- D-glucose
- hexose
- uric acid
- SLC1A5
role in cell
- proliferation
- apoptosis
- activation
- glycolysis in
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc2a12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- circulatory system development
- hexose transport
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- membrane
- endomembrane system
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- D-glucose transmembrane transporter activity
- symporter activity
- glucose transmembrane transporter activity