DOLK Gene Summary [Human]
The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]
Details
| Type | Protein Coding |
| Official Symbol | DOLK |
| Official Name | dolichol kinase [Source:HGNC Symbol;Acc:HGNC:23406] |
| Ensembl ID | ENSG00000175283 |
| Bio databases IDs | |
| Aliases | dolichol kinase, dolichol kinase 1 |
| Synonyms | CDG1M, DK, DK1, dolichol kinase, LOC227697, mKIAA1094, SEC59, TMEM15 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DOLK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- dolichol kinase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital disorder of glycosylation type 1m
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- epithelial uterine cancer
- cervical cancer
- hyperalgesia
regulated by
- GABA
- G protein alpha
regulates
- dolichol monophosphate
- dolichol 20
- dolichyl diphosphate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DOLK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dolichyl monophosphate biosynthetic process
- dolichyl diphosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- dolichol kinase activity