Details
| Type | Immunoglobulin Constant Gene |
| Official Symbol | Ighg1 |
| Official Name | immunoglobulin heavy constant gamma 1 (G1m marker) [Source:MGI Symbol;Acc:MGI:96446] |
| Ensembl ID | ENSMUSG00000076614 |
| Bio databases IDs | |
| Aliases | immunoglobulin heavy constant gamma 1 (G1m marker) |
| Species | Mouse, Mus musculus |
Pathways
Biological processes and signaling networks where the Ighg1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Autoimmune Thyroid Disease Signaling
- B Cell Receptor Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- FcγRIIB Signaling in B Lymphocytes
- IL-12 Signaling and Production in Macrophages
- IL-15 Signaling
- IL-7 Signaling Pathway
- p70S6K Signaling
- Phagosome Formation
- PI3K Signaling in B Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
phenotypes
- abnormal B cell physiology
- abnormal class switch recombination
- abnormal plasma cell differentiation
- absent memory B cells
- decreased IgG1 level
- decreased IgG2c level
- decreased body temperature
- enhanced humoral immune response
- increased IgE level
- increased IgG1 level
- increased IgG2a level
- increased IgG2b level
- increased anti-double stranded DNA antibody level
- increased anti-nuclear antigen antibody level
- increased autoantibody level
- increased germinal center B cell number
- increased plasma cell number
- increased sensitivity to xenobiotic induced morbidity/mortality
- increased susceptibility to type I hypersensitivity reaction