Details
| Type | Immunoglobulin Constant Gene |
| Official Symbol | Ighm |
| Official Name | immunoglobulin heavy constant mu [Source:MGI Symbol;Acc:MGI:96448] |
| Ensembl ID | ENSMUSG00000076617 |
| Bio databases IDs | |
| Aliases | immunoglobulin heavy constant mu |
| Species | Mouse, Mus musculus |
Pathways
Biological processes and signaling networks where the Ighm gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Autoimmune Thyroid Disease Signaling
- B Cell Development
- B Cell Receptor Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- FcγRIIB Signaling in B Lymphocytes
- IL-12 Signaling and Production in Macrophages
- IL-15 Signaling
- IL-7 Signaling Pathway
- p70S6K Signaling
- Phagosome Formation
- PI3K Signaling in B Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
phenotypes
- abnormal B cell activation
- abnormal B cell differentiation
- abnormal B cell physiology
- abnormal B cell proliferation
- abnormal B-1a B cell morphology
- abnormal CD4-positive alpha-beta T cell physiology
- abnormal CD8 positive alpha-beta intraepithelial T cell morphology
- abnormal T cell number
- abnormal T cell proliferation
- abnormal antigen presentation
- abnormal cardiovascular system physiology
- abnormal class switch recombination
- abnormal compact bone morphology
- abnormal complement pathway
- abnormal cytokine secretion
- abnormal follicular dendritic cell antigen presentation
- abnormal humoral immune response
- abnormal immature B cell morphology
- abnormal immune serum protein physiology
- abnormal immune system physiology
- abnormal intestinal epithelium morphology
- abnormal lymphatic vessel morphology
- abnormal mature B cell morphology
- abnormal metallophilic macrophage morphology
- abnormal plasma cell differentiation
- abnormal respiratory system physiology
- abnormal response to infection
- abnormal spleen B cell follicle morphology
- abnormal spleen germinal center morphology
- abnormal spleen marginal sinus morphology
- abnormal spleen marginal zone macrophage morphology
- abnormal spleen marginal zone morphology
- abnormal spleen morphology
- abnormal spleen periarteriolar lymphoid sheath morphology
- abnormal spleen white pulp morphology
- abnormal splenic cell ratio
- abnormal trabecular bone morphology
- absent B cells
- absent follicular dendritic cells
- absent immature B cells
- absent mature B cells
- arrested B cell differentiation
- decreased B cell number
- decreased B cell proliferation
- decreased B-1 B cell number
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased IgA level
- decreased IgE level
- decreased IgG level
- decreased IgG1 level
- decreased IgG2a level
- decreased IgG2b level
- decreased IgG3 level
- decreased IgM level
- decreased Peyer's patch number
- decreased T cell proliferation
- decreased bone mineral density
- decreased compact bone thickness
- decreased compact bone volume
- decreased dendritic cell number
- decreased follicular B cell number
- decreased immature B cell number
- decreased immunoglobulin level
- decreased marginal zone B cell number
- decreased mature B cell number
- decreased plasma cell number
- decreased pre-B cell number
- decreased spleen weight
- decreased susceptibility to autoimmune diabetes
- decreased susceptibility to injury
- decreased susceptibility to type IV hypersensitivity reaction
- decreased trabecular bone thickness
- decreased transitional stage B cell number
- enlarged spleen
- impaired complement classical pathway
- increased B cell derived lymphoma incidence
- increased B cell number
- increased B cell proliferation
- increased B-1 B cell number
- increased IgA level
- increased IgG2a level
- increased IgG3 level
- increased IgM level
- increased anti-double stranded DNA antibody level
- increased autoantibody level
- increased marginal zone B cell number
- increased osteoclast cell number
- increased plasma cell number
- increased pro-B cell number
- increased spleen germinal center number
- increased spleen white pulp amount
- increased susceptibility to Riboviria infection
- increased susceptibility to autoimmune diabetes
- increased susceptibility to induced arthritis
- increased susceptibility to parasitic infection
- insulitis
- kidney inflammation
- no abnormal phenotype detected
- premature death
- small Peyer's patches
- small lymph nodes