Mos Gene Summary [Mouse]
Predicted to enable MAP kinase kinase kinase activity. Involved in several processes, including microtubule cytoskeleton organization; negative regulation of metaphase/anaphase transition of meiotic cell cycle; and positive regulation of MAPK cascade. Acts upstream of or within regulation of meiotic nuclear division. Located in cytoplasm. Is expressed in brain; early conceptus; gonad; large intestine; and metanephros. Orthologous to human MOS (MOS proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mos |
| Official Name | Moloney sarcoma oncogene [Source:MGI Symbol;Acc:MGI:97052] |
| Ensembl ID | ENSMUSG00000078365 |
| Bio databases IDs | |
| Aliases | Moloney sarcoma oncogene |
| Synonyms | C-Mos, Moloney sarcoma oncogene, MOS proto-oncogene, serine/threonine kinase, MSV, OZEMA20, VMOS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mos often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- transcription factor binding
- protein binding
- Protein kinase domain
- MAP kinase kinase kinase
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Mos gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gliosis
- oocyte/zygote/embryo maturation arrest 20
- female infertility
- neoplastic cell transformation
- germ cell neoplasia
- infection by HIV-1
role in cell
- expression in
- apoptosis
- phosphorylation in
- activation
- cell viability
- migration
- degeneration
- degradation
- quantity
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mos gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- oocyte maturation
- signal transduction
- positive regulation of ERK1 and ERK2 cascade
- regulation of meiosis
- establishment of meiotic spindle orientation
- protein autophosphorylation
- positive regulation of MAPK cascade
- chromatin organization
- meiotic spindle organization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- MAP kinase kinase kinase activity
- protein serine/threonine kinase activity