Crnn Gene Summary [Mouse]
Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of cell cycle G1/S phase transition; and positive regulation of keratinocyte proliferation. Predicted to be located in cytoplasm and membrane. Is expressed in epidermis; esophagus epithelium; and nail. Orthologous to human CRNN (cornulin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crnn |
| Official Name | cornulin [Source:MGI Symbol;Acc:MGI:2685861] |
| Ensembl ID | ENSMUSG00000078657 |
| Bio databases IDs | |
| Aliases | cornulin |
| Synonyms | C1orf10, cornulin, DRC-1, Gm1015, PDRC1, RGD1311778, SEP53 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crnn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- S-100/ICaBP type calcium binding domain
- EF-hand domain pair
- EFh
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crnn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of keratinocyte proliferation
- regulation of protein kinase B signaling cascade
- response to heat
- regulation of gene expression
- cellular response to cytokine stimulus
- positive regulation of NF-kappaB transcription factor activity
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- transition metal ion binding
- protein binding
- calcium ion binding
- calcium-dependent protein binding