CRNN Gene Summary [Human]
This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | CRNN |
| Official Name | cornulin [Source:HGNC Symbol;Acc:HGNC:1230] |
| Ensembl ID | ENSG00000143536 |
| Bio databases IDs | |
| Aliases | cornulin |
| Synonyms | C1orf10, cornulin, DRC-1, Gm1015, PDRC1, RGD1311778, SEP53 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CRNN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- S-100/ICaBP type calcium binding domain
- EF-hand domain pair
- EFh
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CRNN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of keratinocyte proliferation
- regulation of protein kinase B signaling cascade
- response to heat
- regulation of gene expression
- cellular response to cytokine stimulus
- positive regulation of NF-kappaB transcription factor activity
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- transition metal ion binding
- protein binding
- calcium ion binding
- calcium-dependent protein binding