Ube2v1 Gene Summary [Mouse]
Enables ubiquitin conjugating enzyme binding activity. Contributes to ubiquitin conjugating enzyme activity. Acts upstream of or within error-free postreplication DNA repair. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of UBC13-MMS2 complex and ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human UBE2V1 (ubiquitin conjugating enzyme E2 V1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2v1 |
| Official Name | ubiquitin-conjugating enzyme E2 variant 1 [Source:MGI Symbol;Acc:MGI:1913839] |
| Ensembl ID | ENSMUSG00000078923 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2 variant 1 |
| Synonyms | 0610011J09Rik, CIR1, CROC-1, D7Bwg1382e, MGC8586, UBE2V, UBE2V1 isoform 1, ubiquitin conjugating enzyme E2 V1, Ubiquitin-conjugating enzyme e2 variant 1, UEV-1, UEV1A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube2v1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin conjugating enzyme
- enzyme binding
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ube2v1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal carcinomagenesis
- colon adenocarcinoma
- colon epithelial cancer
- rectal adenocarcinoma
- rectum cancer
role in cell
- cell death
- apoptosis
- restriction in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- cellular membrane
- cytosol
- nucleoplasm
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube2v1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- protein polyubiquitination
- regulation of DNA repair
- cell differentiation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- protein K63-linked ubiquitination
- regulation of transcription, DNA-dependent
- positive regulation of NF-kappaB transcription factor activity
- postreplication repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- UBC13-MMS2 complex
- ubiquitin ligase complex
- cytoplasm
- ubiquitin conjugating enzyme complex
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding