Samd1 Gene Summary [Mouse]
Enables low-density lipoprotein particle binding activity. Involved in foam cell differentiation; lipoprotein lipid oxidation; and negative regulation of transcription by RNA polymerase II. Is active in extracellular space. Is expressed in several structures, including alimentary system; extraembryonic component; hemolymphoid system gland; umbilical artery; and umbilical vein. Orthologous to human SAMD1 (sterile alpha motif domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Samd1 |
| Official Name | sterile alpha motif domain containing 1 [Source:MGI Symbol;Acc:MGI:2142433] |
| Ensembl ID | ENSMUSG00000079003 |
| Bio databases IDs | |
| Aliases | sterile alpha motif domain containing 1 |
| Synonyms | AA589507, LOC100509016, LOC90378, NTIA01000060.1, RGD1305094, sterile alpha motif domain containing 1, sterile α motif domain containing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Samd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- SAM (Sterile alpha motif )
- chromatin binding
- protein binding
- low-density lipoprotein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Samd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- protein homooligomerization
- foam cell differentiation
- lipoprotein lipid oxidation
- chromatin organization
- regulation of methylation-dependent chromatin silencing
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- chromosome
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- chromatin binding
- low-density lipoprotein particle binding