Samd1 Gene Summary [Rat]
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | Samd1 |
| Official Name | sterile alpha motif domain containing 1 [Source:RGD Symbol;Acc:7529921] |
| Ensembl ID | ENSRNOG00000052637 |
| Bio databases IDs | |
| Aliases | sterile alpha motif domain containing 1 |
| Synonyms | AA589507, LOC100509016, LOC90378, NTIA01000060.1, RGD1305094, sterile alpha motif domain containing 1, sterile α motif domain containing 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Samd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- SAM (Sterile alpha motif )
- chromatin binding
- protein binding
- low-density lipoprotein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- exencephaly
- bleeding
- edema
- growth failure
role in cell
- number
- differentiation
- cohesion
- cohesion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Samd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- protein homooligomerization
- foam cell differentiation
- lipoprotein lipid oxidation
- chromatin organization
- regulation of methylation-dependent chromatin silencing
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- chromosome
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- chromatin binding
- low-density lipoprotein particle binding