icon_0328_cc_gen_hmr_bacteria-s

Renal Cell Carcinoma Signaling

Renal cell carcinoma (RCC) refers to various neoplasms of renal origin. The four major histological subtypes are conventional (clear cell RCC), papillary, chromophobic, and collecting duct. Four genes have been well studied in the hereditary form of renal carcinoma. These are von Hippel-Lindau(VHL), MET, fumarate hydratase (FH) and Birt Hogg Dube (BHD).VHL associated tumors are clear cell carcinomas...

Renal Cell Carcinoma Signaling

Pathway Summary

Renal cell carcinoma (RCC) refers to various neoplasms of renal origin. The four major histological subtypes are conventional (clear cell RCC), papillary, chromophobic, and collecting duct. Four genes have been well studied in the hereditary form of renal carcinoma. These are von Hippel-Lindau(VHL), MET, fumarate hydratase (FH) and Birt Hogg Dube (BHD).VHL associated tumors are clear cell carcinomas. Mutations in the VHL gene prevent the ubiquitination of HIF-1α leading to its accumulation. This results in the production of growth factors that enhance angiogenesis and cell growth. Mutations in the FH gene cause hereditary leiomyomatosis and renal cancer syndrome papillary renal tumors. Mutations in FH also lead to accumulation of fumarate in the cell eventually preventing VHL-mediated degradation of HIF-alpha.The oncogene MET has also been implicated in hereditary papillary renal cancer. Activating mutations in the tyrosine kinase domain of MET lead to changes in cell motility, cellular transformation, prevention of apoptosis and metastasis. BHD is a novel tumor supressor gene whose function in normal cells and role in RCC is yet to be determined.

Renal Cell Carcinoma Signaling Genes list

Explore Genes related to Renal Cell Carcinoma Signaling

Products related to Renal Cell Carcinoma Signaling

Explore products related to Renal Cell Carcinoma Signaling
GeneGlobe ID: SBHS-058Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human PI3K-AKT Signaling Pathway
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-032Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Hypoxia Signaling Pathway
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-061Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human MAP Kinase Signaling Pathway
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-033Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Cancer PathwayFinder
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-061Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human MAP Kinase Signaling Pathway
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-058Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human PI3K-AKT Signaling Pathway
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-033Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Cancer PathwayFinder
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-032Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Hypoxia Signaling Pathway
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: PAHS-058Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human PI3K-AKT Signaling Pathway
RT2 Profiler PCR Array
Product Specification
Copy Details
GeneGlobe ID: PAHS-061Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human MAP Kinase Signaling Pathway
RT2 Profiler PCR Array
Product Specification
Copy Details
GeneGlobe ID: PAHS-033Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Cancer PathwayFinder™
RT2 Profiler PCR Array
Product Specification
Copy Details

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.