Btbd18 Gene Summary [Mouse]
Involved in male meiosis I; piRNA transcription; and spermatogenesis. Acts upstream of with a positive effect on transposable element silencing. Located in nucleus. Is expressed in several structures, including diencephalon; genitourinary system; gut; liver; and spleen. Orthologous to human BTBD18 (BTB domain containing 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Btbd18 |
| Official Name | BTB (POZ) domain containing 18 [Source:MGI Symbol;Acc:MGI:3650217] |
| Ensembl ID | ENSMUSG00000086598 |
| Bio databases IDs | |
| Aliases | BTB (POZ) domain containing 18 |
| Synonyms | Btbd18-ps, BTB domain containing 18, Gm13718 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Btbd18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Btbd18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- negative regulation of transposition, RNA-mediated
- spermatogenesis
- male meiosis I
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding