Slc5a3 Gene Summary [Mouse]
Predicted to enable potassium channel regulator activity; solute:sodium symporter activity; and transmembrane transporter binding activity. Involved in regulation of transporter activity. Acts upstream of or within several processes, including inositol metabolic process; myo-inositol transport; and positive regulation of reactive oxygen species biosynthetic process. Located in apical plasma membrane and basolateral plasma membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human SLC5A3 (solute carrier family 5 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc5a3 |
| Official Name | solute carrier family 5 (inositol transporters), member 3 [Source:MGI Symbol;Acc:MGI:1858226] |
| Ensembl ID | ENSMUSG00000089774 |
| Bio databases IDs | |
| Aliases | solute carrier family 5 (inositol transporters), member 3 |
| Synonyms | BCW2, BF642829, Na/Myoinositol Cotransporter, SMIT, SMIT1, SMIT2, solute carrier family 5 (inositol transporters), member 3, solute carrier family 5 member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc5a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pentose transporter
- glucose:sodium symporter
- fucose transporter
- myo-inositol:sodium symporter
- potassium channel regulator
- myo-inositol transporter
- ion channel binding
- protein binding
- polyol transporter
- Solute carrier families 5 and 6-like; solute binding domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metastatic colorectal cancer
- Alzheimer disease
- cyanosis
- respiratory failure
- major depression
- apnea
- papillary renal cell carcinoma
- papillary renal cell neoplasia
- renal cell cancer
regulates
- Ca2+
- reactive oxygen species
- myo-inositol
- D-glucose
- inositol triphosphate
- phosphatidylinositol phosphate
- KCNQ1
- phosphatidylinositol 4,5-bisphosphate
- KCNQ2/3
role in cell
- activation in
- production in
- volume
- action potential by
- discharge
- inactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear region
- cellular membrane
- apical membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc5a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pentose transport
- inositol metabolic process
- positive regulation of catalytic activity
- polyol transport
- peripheral nervous system development
- sodium ion transmembrane transport
- regulation of respiratory gaseous exchange
- fucose transport
- myo-inositol transport
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- voltage-gated potassium channel complex
- membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- pentose transmembrane transporter activity
- protein binding
- polyol transmembrane transporter activity
- fucose transmembrane transporter activity
- myo-inositol transmembrane transporter activity
- myo-inositol:sodium symporter activity
- ion channel binding
- potassium channel regulator activity
- glucose:sodium symporter activity